Blood profile of implantation stainless steel 316L local implant material on rat femoral bone

. Gustian; H. Soehartono; N. Jujur; A.H. S. Wargadipura; D. Noviana

doi:10.14334/jitv.v23i3.1836

Blood profile of implantation stainless steel 316L local implant material on rat femoral bone

. Gustian, H. Soehartono, N. Jujur, A.H. S. Wargadipura, D. Noviana

DOI

https://doi.org/10.14334/jitv.v23i3.1836

Abstract

This study was aimed to obtain information regarding complete blood count (CBC) profile of post implantation of stainless steel (SS) 316L as an Indonesian local product of non-degradable metal implant. Thirty adult male rat, aged approximately 12 weeks were divided into 3 groups, i.e. control group without implantation, implant group with import SS316L and implant group with Indonesian national local SS316L that developed by Agency for the Assessment and Application of Technology (BPPT). The implant groups were given implants by inserting it between femoral bone and biceps femoris muscle. On the control group, defect was made on bone without inserting an implants material. Examination of the systemic response was done with CBC before and 30 days after implantation. The analysis of red blood cells amount, haemoglobin level, haematocrite value, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), total white blood cell and its differentiation from each group did not show significant differences. In conclusion, stainless steel 316L of import and national local product showed non-negative effects on blood profile.

Keywords

Stainless Steel; Metal Implant; Biocompatibility; Blood Profile; Foreign Body Reaction

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References

Anderson JM, Rodriguez A, Chang DT. 2008. Foreign body reaction to biomaterials. Sem Immunol. 20(2):86-100.

Anderson JM. 2001. Biological responses to materials. Annu Rev Mater Res. 31:81-110.

[BPS] Badan Pusat Statistik. 2012. Data ekpor-impor berdasarkan komoditi HS 8458-8463 tahun 2005â€“2012. [accessed December 13th 2017]. https://www. bps.go.id/publikasi.html.

Bombac D, Brojan MP, Fajfar F, Kosel, Turk R. 2007. Review of materials in medical aplications. RMZ-Mat Geo env. 54(4):471-499.

Fitria L, Sarto M. 2014. Profil hematologi tikus (Rattus norvegicus) galur wistar jantan dan betina umur 4, 6, dan 8 minggu. Biogenesis. 2(2): 94-100.

Hafizi I, Widjijono W, Soesatyo MHN. 2016. Penentuan konsentrasi stainless steel 316L dan kobalt kromium remanium GM-800 pada uji GPMT. Majalah Kedokteran Gigi Indonesia. 2(3):16-18.

Hamidi MFFA, Harun WSW, Samykano M, Ghani SAC, Ghazalli Z, Ahmad F, Sulong AB. 2017. A Review of biocompatible metal injection moulding process parameters for biomedical applications. Mat Sci Eng. Elsevier. 78:1263-1276.

Hermawan H, Ramdan D, Djuansjah RP. 2011. Metals for Biomedical Applications. Biomedical Engineering â€“ From Theory to Applications. InTech Publishers

Jujur N, Sah J, Bakri A, Wargadipura AHS. 2015. Analysis of oxide inclusions on medical grade 316L stainless steel using local raw. J Int Tech. 7:1184-1190.

[Kemenkes RI] Kementrian Kesehatan Republik Indonesia. 2013. Riset kesehatan dasar. Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. [accessed December 17th 2017]. www.depkes.go.id/ resources/download/general /Hasil%20Riskesdas%202013.pdf.

Kennedy RC, Marmor M, Marcucio R,Hunt AC. 2018. Simulation enabled search for explanatory mechanisms of the fracture healing process. PLOS J Comp Biol.

Keohane, E.M., Smith, L.J., and Walenga, J.M. 2015. Rodaks's Hematology: Clinical Principles and Applications 5th Ed. St. Louis (Missouri): Elsevier/Saunders. ISBN 978-0-323-23906-6.

Krecisz B, Kiec-Swierczynska M, Bakowic-Mitura K. 2006. Allergy to metals as a cause of orthopedic implant failure. Int Journal Med Env Health. 19(3):178-80.

Larsson TF, Martinez JMM, Valles JL. 2007. Biomaterials for Healthcare. A Decade of EU-Funded Research. Belgium: Directorate General For Research, Industrial Technologies Unit.

Lely SRM, Siswanto B, Aziz I, Anggraini AH. 2012. Effect of Nitrogen Ion Dose on The Corrosion Resistance, The Microstructure an The Phase Structure of The Biomaterial Austenitic Stainless Steel 316L. Yogyakarta: Pusat Sains dan Teknologi Akselerator, BATAN.

Manivasagam G, Dhinasekaran D, Rajaminickam A. 2010. Biomedical implants: corrosion and its prevention â€“ a review. Recent Patents on Corrosion Science. 2: 40-54.

McClung MR, Harvey NC, Fitzpatrick LA, Miller PD, Hattersley G, Wang Y, Cosman F. 2018. Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis. Epub Menopause.

Nielsen E, Bonsu N, Andras LM, Goldstein RY. 2018. The effect of canal fill on paediatric femur fractures treated with titanium elastic nails. J Child Ortho. 12(1):15-19.

Perren SM, Regazzoni P, Fernandez AA. 2017. How to choose between the implant materials steel and titanium in orthopedic trauma surgery: Part 2-biological aspects. Acta Chir Orthopaedic Traumatologie Cechoslovaca. 84(2):85-90.

[PTM-BPPT] Pusat Teknologi Material Badan Pengkajian dan Penerapan Teknologi. 2017. Kegiatan dan Kerjasama Pusat Teknologi Material BPPT.

Saputri DNE, Dyah N, Abdulgani N. 2012. Jumlah Total dan Diferensial Leukosit Mencit (Musculus) pada Evaluasi In Vivo Antikanker Ekstrak Spons Laut Aaptos Suberitoides. Surabaya: Bagian Program Studi Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam Institut Teknologi Sepuluh Nopember.

Sinno H, Prakash S. 2013. Complements and the wound healing cascade [review]. Plastic Surgery International. doi: 10.1155/2013/146764.

Steel RGD, Torrie JH. 1995. Principles and procedures of statistic. A Biometrical Approach. 2 nd ed. New York (USA): Mc Graw Hill Book Co.