Chemical and Biological Characteristics of Anacardic acid as a Bioactive Compound and Its Application on Ruminant

Elizabeth Wina, Andi Saenab

Abstract

The use of bioactive compounds from plants is becoming a major interest to be used as feed additives to reduce the effect of greenhouse gases on climate changes and as an alternative to antibiotic growth promoter. One of the compounds that have not been widely known and used is anacardic acid. In Indonesia, anacardic acid and its derivates are commonly found in the waste from the cashew nut industry, namely cashew nut shells. The purpose of this paper is to describe the chemical and biological characteristics of anacardic acid and its effects on rumen fermentation and ruminant production. Anacardic acid or cashew nut shell extract that contains anacardic acid have the ability to suppress methane produced in the rumen. In addition, this compound increases propionic acid in the rumen which is useful for ruminant. Up till now, the applications of anacardic acid for ruminants that described in published papers were mostly done in vitro, while its direct application to livestock has not been widely reported and most of its use is combined with other compounds. The utilization of anacardic acid in Indonesia as a feed additive for ruminants will contribute to reducing greenhouse gases and increasing the productivity of ruminants.

Keywords

anacardic acid; chemical; biological characteristics; methane; ruminant

Full Text:

PDF

References

Branco AF, Giallongo F, Frederick T, Weeks H, Oh J, Hristov AN. 2015. Effect of technical cashew nut shell liquid on rumen methane emission and lactation performance of dairy cows. J Dairy Sci. 98:4030-4040. doi: 10.3168/jds.2014-9015.

Coutinho DA, Branco AF, dos Santos GT, Osmari MP, Teodoro AL, Diaz TG. 2014. Intake, digestibility of nutrients, milk production and composition in dairy cows fed on diets containing cashew nut shell liquid. Acta Scientiarum Anim Sci Maringá. 36:311-316. doi: 10.4025/actascianimsci.v36i3.2351.

Da Silva FFM, de Medeiros Costa AK, Barbosa PT, de Paiva Mota JC, de Lemos TLG, de Sousa EYA, Silva KA, de Morais SM. 2018. Extraction, isolation and chemical modification of the anacardic acids from the peel of the cashew nuts (Anacardium occidentale L.) and biological assay. Curr Res Bioorg Org Chem. 2018:1-9. doi: 10.29011/CRBOC-110. 100010.

Danielsson R,Werner-Omazic A, Ramin M,Schnürer A, Griinari M, Dicksved J, Bertilsson J. 2014. Effects on enteric methane production and bacterial and archaeal communities by the addition of cashew nut shell extract or glycerol - An in vitro evaluation. J Dairy Sci. 97:5729–5741. doi: 10.3168/jds.2014-7929.

Georgieva K, Popova M, Dimitrova L, Trusheva B, Thanh LN, Phuong DTL, Lien NTP, Najdenski H, Bankova V. 2019. Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae. PLoS ONE. 14:e0216074. doi: 10.1371/journal.pone.0216074.

Hamad FB, Mubofu EB. 2015. Potential biological applications of bio-based anacardic acids and their derivatives. Int J Mol Sci. 16:8569-8590. doi: 10.3390/ijms16048569.

Hayashi A, Taniguchi N, Tsujimoto K, Kubo I. 2007. Mass spectrometric elucidation of phenolic oxidation process with Cu 2+ -adducts. J Mass Spectrom Soc Jpn. 55:7-13.

Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Ali SR, Kunkel MT, Lin AE, Forli S, Newton AC, Geetha B. Kumar GB, Nair BG, Jefferson J, Perry P, Nizet V. 2016. Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity. J Biol Chem. 291:13964–13973.

Jiang X, Zhang H, Mehmood K, Li K, Zhang LH, Yao WY, Tong XO, Li Ay, Wang YP, Jiang JH, Iqbal M, Waqas M, Li, JK. 2019. Effect of anacardic acid against thiram induced tibial dyschondroplasia in chickens via regulation of Wnt4 expression. Animal 82:1-10. doi: 10.3390/ani9030082.

Kang SC, Suzuki R, Suzuki Y, Koike S, Nagashima K, Kobayashi Y. 2018. Rumen responses to dietary supplementation with cashew nut shell liquid and its cessation in sheep. Anim Sci J. 89:1549-1555. doi: 10.1111/asj.13100.

Maeda K, Nguyen VT, Suzuki T, Yamada K, Kudo K, Hikita C, Phong Le VP, Nguyen MC, Yoshida N. 2021. Network analysis and functional estimation of the microbiome reveal the effects of cashew nut shell liquid feeding on methanogen behaviour in the rumen. Microbial Biotechnol. 14:277–290. doi: 10.1111/1751-7915.13702.

Mitsumori M, Enishi O, Shinkai T, Higuchi K, Kobayashi Y, Takenaka A, Nagashima K, Mochizuki M, Kobayashi Y. 2014. Effect of cashew nut shell liquid on metabolic hydrogen flow on bovine rumen fermentation. Anim Sci J. 85:227–232.

Morais SM, Silva KA, Araujo H, Vieira IGP, Alves DR, Fontenelle ROS, Silva AMS. 2017. Anacardic acid constituents from cashew nut shell liquid: NMR characterization and the effect of unsaturation on its biological activities. Pharmaceuticals. 10:1-10. doi: 10.3390/ph10010031.

Nagabhushana KS, Shobha SV, Ravindrana B. 1995. Selective ionophoric properties of anacardic acid. J Nat Prod. 58:807-810.

Njuku FW, Mwangi PM, Thiong’o GT. 2014. Evaluation of cardanol acetate as a reactive diluent of alkyd coatings. Int J Adv Res. 2:928-941.

Oh S, Shintani R, Koike S, Kobayashi Y. 2016. Ginkgo fruit extract as an additive to modify rumen microbiota and fermentation and to mitigate methane production. J Dairy Sci. 100:1923–1934. doi: 10.3168/jds.2016-11928.

Oh S, Suzuki Y, Hayashi S, Suzuki Y, Koike S, Kobayashi Y. 2017. Potency of cashew nut shell liquid in rumen modulation under different dietary conditions and indication of its surfactant action against rumen bacteria. J Anim Sci Technol. 59:27-34. doi: 10.1186/s40781-017-0150-8.

Osmari MP, Branco AF, Goes RHTB, Diaz TG, Matos LF. 2017. Increasing dietary doses of cashew nut shell liquid on rumen and intestinal digestibility of nutrient in steers fed a high-grain diet. Arch Zootecnia. 66:375-381.

Popova M, Trusheva B, Ilieva N, Thanh LN, Lien NTP, Bankova V. 2021. Mangifera indica as propolis source: what Mangifera indica as propolis source: what exactly do bees collect?. BMC Res Notes 14:448. doi: 10.1186/s13104-021-05863-7.

Ramírez-Gómez XS, Jiménez-García SN, Campos VB and Campos MLG. 2020. Plant metabolites in plant defense against pathogens. In: Topolovec-Pintaric S, editor. Plant Diseases - Current Threats and Management Trends. Chapter 4. IntechOpen. doi: 10.5772/intechopen.87958.

Saenab A, Wiryawan KG, Retnani Y, Wina E. 2016. Karakteristik fisik dan kimia dari produk bioindustry cangkang jambu mete (Anacardium occidentale) J Littri. 22:81-90. doi: 10.21082/littri.v22n2.2016.81-90.

Saenab A, Wiryawan KG, Retnani Y , Wina E. 2017. Anacardic acid isolated from cashew nut shell (Anacardium occidentale) affects methane and other products in the rumen fermentation. Media Peternakan. 40:94-100. doi: 10.5398/medpet.2017.40.2.94.

Saenab A, Wiryawan KG, Retnani Y, Wina E. 2018 Manipulation of rumen fermentation by bioindustrial products of cashew nut shell (Anacardium occidentale) to reduce methane production. JITV 23:61-70. doi: 10.14334/jitv.v23i2.1821.

Salehi B, Gültekin-Özgüven M, Kırkın C, Özçelik B, Morais-Braga MFB, Carneiro NJP, Bezerra F, da Sliva TG, Coutinho HDM, Amina B, Amstrong L, Selamoglu Z, Sevindik M, Yousaf Z, Sharifi-Rad J, Muddathir AM, Devkota HP, Martorell M, Jugran AK, Martins B, Cho WC. et al. 2019. Anacardium plants: Chemical, nutritional composition and biotechnological applications. Biomolecules. 9:1-34. doi: 10.3390/biom9090465.

Scorzza C, Nieves J, Vejar F, Bullon J. 2010. Synthesis and physicochemical characterization of anionic surfactants derived from cashew nut shell oil. J Surfact Deterg. 13:27–31. doi: 10.1007/s11743-009-1143-5.

Shinkai T, Enishi O, Mitsumori M, Higuchi K, Kobayashi Y, Takenaka A, Nagashima K, Mochizuki M, Kobayashi Y.2012. Mitigation of methane production from cattle by feeding cashew nut shell liquid. J Dairy Sci. 95:5308–5316.

Silva MSS, De Lima SG, Oliveira EH, Lopes JAD, Chaves MH, Reis FAM, Citó AMGL. 2008. Anacardic acid derivatives from brazilian propolis and their antibacterial activity. Ecl Quím São Paulo. 33:53-58.

Sinurat AP, Wina E, Rakhmani SIW, Wardhani T, Haryati T, Purwadaria T. 2018. Bioactive substances of some herbals and their effectiveness as antioxidant, antibacteria and antifungi. JITV. 23:18-27. doi: doi: 10.14334/jitv.v23i1.1660.

Stasiuk M, Kozubek A. 2010. Biological activity of phenolic lipids. Cell Mol Life Sci. 67:841–860. doi 10.1007/s00018-009-0193-1.

Suo MR, Isao H, Ishida Y, Shimano Y, Bi CX, Kato H, Takano F, Ohta T. 2012.Phenolic lipid ingredients from cashew nuts. J Nat Med. 66:133–139. doi: 10.1007/s11418-011-0564-4.

Trevisan MT, Pfundstein B, Haubner R, Würtele G, Spiegelhalder B, Bartsch H, Owen RW 2006. Characterization of alkyl phenols in cashew (Anacardium occidentale) products and assay of their antioxidant capacity. Food Chem Toxicol. 44:188–197. doi: 10.1016/j.fct.2005.06.012.

Tsujimoto K, Hayashi A, Ha TJ, Kubo I. 2007. Anacardic acids and ferric ion chelation. Zeitschrift für Naturforschung C. 62c:710-716. doi: 10.1515/znc-2007-9-1014.

Tyman JHP. 2001. Chemistry and biochemistry of anacardic acids. Recent Res Dev Lipids. 5:125–145.

Valero MV, Farias MS, Zawadzki F, Prado RM, Fugita CA, Rivaroli DC, Ornaghi MG, Prado IN. 2016. Feeding propolis or essential oils (cashew and castor) to bulls: performance, digestibility, and blood cell counts. Rev Colomb Cienc Pecu. 29:33-42.

Watanabe Y, Suzuki R, Koike S, NagashimaK, Mochizuki M, Forster RJ, Kobayashi Y. 2010. In vitro evaluation of cashew nut shell liquid as a methane-inhibiting and propionate-enhancing agent for ruminants. J Dairy Sci. 93:5258–5267.

Refbacks

  • There are currently no refbacks.

Copyright (c)  2022 WARTAZOA. Indonesian Bulletin of Animal and Veterinary Sciences

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

View My Stats